Anthony Hornof's research is in human-computer interaction. He is interested in making computers easier for people to use and learn, in finding new ways for people to use computers, and in supporting patterns of human creativity and expression. He has active research projects in cognitive modeling, eye tracking, and assistive technology.

Cognitive Modeling. Cognitive models are computer programs that simulate the human perceptual, cognitive, and motor processes that people use when interacting with a computer. Cognitive modeling provide a scientific base to human-computer interface design, and can help interface designers understand how a person is likely to use a computer interface to accomplish a task.
Multimodal Multitasking. This project aims to explain and predict user performance in complex auditory and visual multitask environments through computational modeling and empirical human data collection, including eye tracking.
Assistive Technology. Dr. Hornof collaborates with children with severe motor impairments and their caregivers in participatory design activities aimed at developing new technology to meet these children's developmental, communication, and creative needs.
EyeDraw uses eye tracking to permit creative expression through eye movements for children with severe motor impairments. EyeDraw is now distributed with a commercial eye tracker and enables children with disabilities to draw pictures by just moving their eyes.
EyeMusic has been developed in collaboration with new media artists and musicians. EyeMusic--a set of eye-controlled compositions--has been performed at leading international computer music conferences.